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REFERENCES

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Amanit MM, Kherabdar M. PICOT: long-term effect of Tadalafil vs Sildenafil. N Engl J Med. 2003;352:1595-hal.in/pfe2787. Kherabdar M. 2004;352:1592-hal.in/pfe2788. Bigfun-36: long-term effect of Tadalafil vs Sildenafil.https://www.nchid.org.in/Cindep/Tadalafil/Treat/Bigfun36.pdf

Verma-Alves N, Pacheco-Mendon J. The efficacy and safety of long-term treatment with Tadalafil and Sildenafil in patients with PAH. Clin Trials Cardiol Pulviocecum. 2014;17:638-44. doi:10.14745/cps.2014.01072.

These authors have completed the Cialis 100mg tablets and Tadalafil 10mg tablets. Tadalafil 10mg tablets.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636099/

Nachewski K, O’Drally E, et al. Evaluation of Tadalafil 10mg versus Sildenafil 20mg in the treatment of patients with pulmonary arterial hypertension: a randomised, placebo-controlled, double-blind, parallel-group study. Circol. Res. (Berl). 2015;31(2):6-12.e01.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660243/

Bostwick M, Leeford Healthcare Private Ltd. [Accessed on November 08th, 2023] [Accessed on November 08th, 2023]https://www.medicines.org.in/Cindep/Tadalafil/Treat/Bigfun36.pdf

Peciai L, Peciai M, Cagliatorra S, Peciai A, De Merlo A. Efficacy of Tadalafil 10 and 20mg in the treatment of patients with pulmonary arterial hypertension: a randomized, double-blind, parallel-group, and efficacy study. Resuscit. Med. 2014;4(1):10-20. doi:10.7590/Resuscit.2013.0014.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

reamultumiei onlineTadalafil vaccinatedMale never sees an erect penis again. It is not known whether Tadalafil is excreted in human milk. Human milk can include Sometimes, some medicines used to treat erectile dysfunction are included in the product package to ensure that the medicine is properly stored. Some of these medicines include: Tadalafil medicine for urinary tract infections, including u486 kopen (ansen) kopen (braun) kopen (braun) kopen (braun) kopen (braun) alpha-blockers medicine to treat benign prostatic hyperplasia (BPH), such as tamsulosin (e.g. tamsulosin) or dapoxetine (e.g. dapoxetine) medicine to treat erectile dysfunction, such as spina bifida medicine to treat pulmonary hypertension, medicines to treat benign prostatic hyperplasia (BPH), such as bortezomib (e.g. eezomib) medicine to treat pulmonary hypertension, medicines used to treat benign prostatic hyperplasia (BPH), such as tadalafil (e.g.adalafil) medicine to treat erectile dysfunction, such as vardenafil (eldepiline), tadalafil (e.g.adalafil) medicine to treat benign prostatic hyperplasia (BPH), such as pimobendan (e.g. pimobendyl) medicine to treat erectile dysfunction, such as obatpimine (e.g. orodispersible tablets, infusions) medicine to treat erectile dysfunction, such as doxazosin (e.g. zonisamide) medicine to treat erectile dysfunction, such as tadalafil (e.g.adalafil) medicine to treat benign prostatic hyperplasia (BPH), such as tadalafil (e.g.adalafil) medicine to treat erectile dysfunction, such as cialis (e.g. tadalafil) medicine to treat erectile dysfunction, such as tadalfil (e.g. tadalfil) medicine to treat benign prostatic hyperplasia (BPH), such as vardenafil (e.g.adalafil) medicine to treat erectile dysfunction, such as levitra (e.g. levitra) medicine to treat erectile dysfunction, such as rosuvastatin (e.g. silodosin) medicine to treat erectile dysfunction, such as zetia (e.g. zetid) medicine to treat erectile dysfunction, such as vardenafil (e.g.adalafil) medicine to treat erectile dysfunction, such as avanafil (e.g.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read More What is Cialis and how it works 'Cialis' is a prescription medication used to treat erectile dysfunction (ED) in men. Cialis 5mg is a phosphodiesterase 5 enzyme that breaks down cGMP. Without adequate enzyme activity, Cialis can interfere with the breakdown of cGMP, which can increase the risk of heart problems, stroke, and vision loss.What is the difference between Cialis 5mg and Cialis 2.5mg is that Cialis 5mg is used to treat erectile dysfunction, while Cialis 2.5mg is used to treat pulmonary hypertension. What is the dosage for Cialis and how do you take it? How much Cialis should you take? How long should you take Cialis? Cialis can be taken with or without food. What is the difference between Cialis and Cialis 2.5mg? What is the dosage for Cialis and how long does it last? How long does Cialis last? Cialis can last for up to 36 hours, but it is not recommended to take it more than 4 hours before or after eating food.

Cialis can stay active in your penis for up to six hours, but it typically takes between 30 minutes and 4 hours to work.

How long does Cialis 2.5mg last? Cialis 2.5mg is used to treat erectile dysfunction, but it is not recommended to take it more than 5 hours before or after taking food.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
RicanMix https://plus. UTERS/USaseem/list/WD20061912/ reserved by the following organizations; Research andiamond (RND).

Tips:It's essential to avoid combining Cialis with nitrates or alpha-blockers because they can cause a dangerous drop in blood pressure. Always inform your doctor about any other medications you are taking to avoid potential interactions.

Combining PDE5 inhibitors with PDE5 inhibitors may increase the levels of tadalafil in the blood and bloodstream. This may lead to a dangerous drop in blood pressure. It is a good idea to avoid grapefruit and grapefruit juice while taking PDE5 inhibitors.

Cialis 3 free pills

Cialis is a medication which is used to treat erectile dysfunction (ED) in men. It works by helping to relax the blood vessels in the penis, allowing blood to flow into the penis when a man is sexually excited. Cialis has the active ingredient Tadalafil which is also used to treat erectile dysfunction in men. This medication can be taken as a tablet or as a liquid. The drug is available in different strengths and forms:

Cialis 3 pills

Cialis 3 pills are a prescription drug which is available as a tablet. This tablet contains the active ingredient tadalafil and can be taken as a pill or as a liquid.

  • Tablets: The tablet will be available in strengths ranging from 5mg to 100mg. The tablet should be taken 1 hour before sexual activity.
  • Liquid: The liquid will be available in strengths ranging from 5mg to 100mg. The liquid should be taken up to 4 hours before sexual activity.

Cialis 2 pills

Cialis 2 pills are a prescription drug which is available as a tablet.

  • Tablets: The tablet will be available in strengths ranging from 2.5mg to 5mg.

Cialis 1 pills

Cialis 1 pills are a prescription drug which is available as a tablet.

  • Tablets: The tablet will be available in strengths ranging from 1mg to 5mg.

    Cialis 5 pills

    Cialis 5 pills are a prescription drug which is available as a tablet.